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Study identifier: NCT06106529 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

REDucing Hot FLASHes in Women Using Endocrine Therapy.

Condition: Breast Cancer · Hot Flash Due to Medication  ·  Sponsor: Reinier de Graaf Groep

PhasePhase 3
Planned participants260
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this randomized intrapatient cross-over study is to assess the efficacy of oxybutynin versus venlafaxine in reducing hot flashes in women using endocrine therapy after breast cancer. The objectives it aims to answer are: * To assess the efficacy of oxybutynin versus venlafaxine in reducing hot flashes in women using endocrine therapy after breast cancer * To assess side effects of oxybutynin versus venlafaxine. * To assess the personal preference of women for oxybutynin versus venlafaxine in reducing hot flashes. * To assess quality of life of women when reducing hot flashes in women using endocrine therapy after breast cancer. Participants will fill-out a patient diary during 15 weeks total on a daily basis and receive an (online) questionnaire three times total. Researchers will compare two groups (venlafaxine group versus oxubutynine group) to assess its efficacy concerning hot flashes.

This description comes directly from the study's public registry record.

Talk to the study team

Marte Smits, MSc  ·  +31152603870  ·  marte.smits@rdgg.nl

Always discuss trial participation with your own doctor first.

Locations (1)

Reinier de Graaf GasthuisDelft, South Holland, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT06106529