Condition: Alcohol Use Disorder · Stress Reaction · Social Stress · Sponsor: Central Institute of Mental Health, Mannheim
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder. The main questions the projects aims to answer are: What are the neurobehavioral underpinnings of adaptive stress responses and resilience to repeated stress exposure with regards to: * alcohol craving? * alcohol use? * their modulation by prior stress exposure, social interactions, coping strategies and individual health behavior? Participants will: * be exposed to an established experimental stress-induction protocol, the Trier Social Stress Test * be exposed to their favorite drink in a bar lab environment * be assessed using fMRI to determine their neural alcohol cue reactivity, response inhibition, and emotion processing * conduct an ambulatory phase to assess stressors, alcohol craving, substance use and details on social interactions, health behavior and coping strategies using ecological momentary assessment tools.
This description comes directly from the study's public registry record.
Patrick Bach, MD, PhD · +49 621 1703 · patrick.bach@zi-mannheim.de
Judith Zaiser · +49 621 1703 · judith.zaiser@zi-mannheim.de
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| Central Institute of Mental Health | Mannheim, Baden-Wurttemberg, Germany | Recruiting |
| Central Institute of Mental Health | Mannheim, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06105853