Condition: Acute Hypoxemic Respiratory Failure · High-flow Nasal Oxygen Therapy · Sponsor: University Hospital, Tours
High-flow nasal oxygen therapy (HFNO) is an oxygenation technique frequently used in intensive care. The main objective of our study is to show that the use of a protocol for weaning patients off high-flow nasal oxygen therapy (HFNO) in the intensive care unit increases the probability that patients will be weaned from HFNO at Day 7 post-randomisation. This is a open-label multicentre randomised controlled trial conducted in two parallel groups. The primary endpoint is the success rate at Day 7, with success defined as "definitive" weaning from HFNO, i.e. patients weaned from HFNO for more than 48 hours without recourse to non-invasive ventilation (NIV) or intubation and still alive at Day 7. The weaning protocol will be started as soon as the patient meets all the inclusion criteria, considered to be the prerequisites for initiating weaning from HFNO. Patients will be monitored until Day 28 maximum.
This description comes directly from the study's public registry record.
Mai-Anh NAY, MD · 02.38.51.44.46 · mai-anh.nay@chr-orleans.fr
Marie LECLERC · 02.47.47.46.64 · m.leclerc@chu-tours.fr
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| Intensive care, University Hospital, Blois | Blois, France | Recruiting |
| Intensive care unit, University Hospital, Bourg-en-Bresse | Bourg-en-Bresse, France | Recruiting |
| Intensive care, University Hospital, Bourges | Bourges, France | Recruiting |
| Intensive care unit, University Hospital, Caen | Caen, France | Not Yet Recruiting |
| Intensive care, University Hospital, Chartres | Chartres, France | Recruiting |
| Intensive care, University Hospital, Cholet | Cholet, France | Recruiting |
| Intensive care, University Hospital, Dax | Dax, France | Recruiting |
| Intensive care, University Hospital, Le Mans, | Le Mans, France | Recruiting |
| Intensive care, University Hospital, Orléans | Orléans, France | Recruiting |
| Intensive care, University Hospital, Tours | Tours, France | Recruiting |
| Intensive care unit, University Hospital, Vannes | Vannes, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06104956