Condition: HER2-negative Breast Cancer · Advanced Breast Cancer · Sponsor: Guangdong Provincial People's Hospital
This is a phase II, multicenter, open-label, randomized controlled trial to compare the efficacy of organoid-guided treatment (OGT) to treatment of physician's choice (TPC) in previously treated, HER2-negative locally advanced or metastatic breast cancer. The study will seek to provide evidence for utilizing patient-derived organoid (PDO) model to personalize treatment strategies and inform clinical care for advanced breast cancer. Subjects randomized to the OGT group will undergo PDO generation and receive treatment dictated by subsequent PDO drug sensitivity screening. Subjects randomized to the TPC group will receive empirical therapy as selected by the treating physician.
This description comes directly from the study's public registry record.
Kun Wang, M.D. · 00862083827812 · wangkun@gdph.org.cn
Hong-Fei Gao, M.D. · nfzj1988@163.com
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| Guangdong Provincial People's Hospital | Guangzhou, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06102824