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Study identifier: NCT06096844 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

Condition: Advanced Lung Non-Small Cell Carcinoma · Stage IIIB Lung Cancer AJCC v8 · Stage IIIC Lung Cancer AJCC v8  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 3
Planned participants304
Who can joinAll sexes, 70 Years to no upper limit
Healthy volunteersNo

About this study

This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab and chemotherapy may help stabilize lung cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (322)

Highlands Oncology Group - FayettevilleFayetteville, Arkansas, United StatesRecruiting
Mercy Hospital Fort SmithFort Smith, Arkansas, United StatesRecruiting
Highlands Oncology Group - RogersRogers, Arkansas, United StatesRecruiting
Highlands Oncology GroupSpringdale, Arkansas, United StatesRecruiting
Kaiser Permanente DublinDublin, California, United StatesActive Not Recruiting
Kaiser Permanente-FremontFremont, California, United StatesActive Not Recruiting
Kaiser Permanente Fresno Orchard PlazaFresno, California, United StatesActive Not Recruiting
Kaiser Permanente-FresnoFresno, California, United StatesActive Not Recruiting
Kaiser Permanente- Modesto MOB IIModesto, California, United StatesActive Not Recruiting
Kaiser Permanente-ModestoModesto, California, United StatesActive Not Recruiting
Kaiser Permanente-OaklandOakland, California, United StatesActive Not Recruiting
VA Palo Alto Health Care SystemPalo Alto, California, United StatesActive Not Recruiting

+ 310 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06096844