Condition: Osteoarthritis, Knee · Post-traumatic Osteoarthritis · ACL Tear · Sponsor: Brigham and Women's Hospital
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction. This research study will compare metformin to placebo. The placebo tablet looks exactly like metformin, but contains no metformin. Placebos are used in research studies to see if the results are due to the study drug or due to other reasons. Metformin is approved by the U.S. Food and Drug Administration (FDA) to treat type II diabetes. Notably, it also has anti-inflammatory effects, suggesting it could benefit people who have an ACL injury and are undergoing ACL reconstruction.
This description comes directly from the study's public registry record.
Faith Selzer, PhD · 617-525-8617 · fselzer@bwh.harvard.edu
Daniel J Betensky, AB · 6175259727 · dbetensky@bwh.harvard.edu
Always discuss trial participation with your own doctor first.
| Emory University | Atlanta, Georgia, United States | Recruiting |
| University of Iowa Hospitals and Clinics | Iowa City, Iowa, United States | Recruiting |
| University of Kentucky | Lexington, Kentucky, United States | Recruiting |
| Brigham and Women's Hospital | Boston, Massachusetts, United States | Recruiting |
| University of Nebraska Medical Center | Omaha, Nebraska, United States | Recruiting |
| Hospital for Special Surgery | New York, New York, United States | Recruiting |
| The University of North Carolina at Chapel Hill | Chapel Hill, North Carolina, United States | Recruiting |
| Cleveland Clinic | Cleveland, Ohio, United States | Recruiting |
| The Ohio State University | Columbus, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06096259