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Study identifier: NCT06095297 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Long COVID Brain Fog: Cognitive Rehabilitation Trial

Condition: Long COVID · Brain Fog · Cognitive Impairment  ·  Sponsor: University of Alabama at Birmingham

PhaseNA
Planned participants30
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will compare two approaches to cognitive rehabilitation in adults with long COVID with persistent, mild to moderate, cognitive impairment. One approach will feature (A) web-based computer "games" that trains how quickly individuals process information that they receive through their senses; (B) in-lab training on everyday activities with important cognitive components, (C) procedures designed to transfer improvements in cognition from the treatment setting to everyday life, and (D) a non-invasive form of vagus nerve stimulation (VNS), i.e., trans-auricular VNS (taVNS). Component B will include work-related tasks. This approach is termed Constraint-Induced Cognitive Therapy (CICT). The other approach will feature (A) web-based computer "games" that train reaction time and eye-hand coordination; (B) in-lab training on relaxation, healthy nutrition, and healthy sleep, (C) procedures designed to promote integration of these lifestyle changes into everyday life, and (D) taVNS. This approach is termed Brain Fitness Training (BFT). A subset of participants, who qualify for and and desire vocational rehabilitation (VR), will receive VR from the Alabama Department of Rehabilitation Services (ADRS) in addition to CICT or BFT. ADRS VR will include career counseling, prescription of on-the-job accommodations, and guidance on return-to-work. Those in the CICT + VR group will also receive on-the-job coaching from a peer mentor for a month after completing training. CICT, with …

This description comes directly from the study's public registry record.

Talk to the study team

Madeline Rathz, BS  ·  205-934-9768  ·  mgrathz@uab.edu

Helen Bliss, BS  ·  205-934-0433  ·  hmbliss@uab.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Alabama at BirminghamBirmingham, Alabama, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06095297