Condition: Follicular Lymphoma (FL) · Sponsor: Regeneron Pharmaceuticals
This study is researching an experimental drug called odronextamab, referred to as study drug. The study is focused on participants with previously untreated follicular lymphoma (a type of non-Hodgkin lymphoma or NHL). This study will be made up of two parts: Part 1 (non-randomized) and Part 2 (randomized - controlled). The aim of Part 1 of the study is to see how safe and tolerable the study drug is when given alone. The aim of Part 2 of the study is to see how the study drug works compared to rituximab (called the "comparator drug") and chemotherapy (the current standard of care for NHL). Standard of care means the usual medication expected and used when receiving treatment for a condition. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects) * How the study drug affects quality of life and ability to complete routine daily activities.
This description comes directly from the study's public registry record.
Clinical Trials Administrator · 844-734-6643 · clinicaltrials@regeneron.com
Always discuss trial participation with your own doctor first.
| University of Arizona Cancer Center | Tucson, Arizona, United States | Recruiting |
| David Geffen School of Medicine at UCLA | Los Angeles, California, United States | Recruiting |
| UC Irvine Health | Orange, California, United States | Withdrawn |
| Investigative Clinical Research of Indiana | Noblesville, Indiana, United States | Recruiting |
| Beth Israel Deaconess Medical Center | Boston, Massachusetts, United States | Recruiting |
| Karmanos Cancer Institute | Detroit, Michigan, United States | Recruiting |
| Hattiesburg Clinic | Hattiesburg, Mississippi, United States | Completed |
| Icahn School of Medicine at Mt Sinai | New York, New York, United States | Recruiting |
| Stony Brook University Hospital | Stony Brook, New York, United States | Recruiting |
| Clinical Research Alliance Inc | Westbury, New York, United States | Withdrawn |
| University of North Carolina | Chapel Hill, North Carolina, United States | Recruiting |
| Levine Cancer Institute | Charlotte, North Carolina, United States | Recruiting |
+ 178 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06091254