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Study identifier: NCT06090539 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas

Condition: Relapsed/Refractory Non-Hodgkin Lymphoma  ·  Sponsor: Bristol-Myers Squibb

PhasePhase 1/Phase 2
Planned participants460
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.

This description comes directly from the study's public registry record.

Talk to the study team

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com  ·  855-907-3286  ·  Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

Always discuss trial participation with your own doctor first.

Locations (67)

Mayo Clinic in Arizona - PhoenixPhoenix, Arizona, United StatesRecruiting
City of Hope Comprehensive Cancer CenterDuarte, California, United StatesRecruiting
Local Institution - 0068Jacksonville, Florida, United StatesNot Yet Recruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Mayo Clinic in Rochester, MinnesotaRochester, Minnesota, United StatesRecruiting
Local Institution - 0124Omaha, Nebraska, United StatesNot Yet Recruiting
Local Institution - 0047Lake Success, New York, United StatesCompleted
Local Institution - 0037New York, New York, United StatesNot Yet Recruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Local Institution - 0045Providence, Rhode Island, United StatesNot Yet Recruiting
Local Institution - 0118Antofagasta, AN, ChileNot Yet Recruiting

+ 55 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06090539