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Study identifier: NCT06088732 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression

Condition: Bipolar Depression  ·  Sponsor: Laureate Institute for Brain Research, Inc.

PhasePhase 1/Phase 2
Planned participants20
Who can joinAll sexes, 18 Years to 55 Years
Healthy volunteersNo

About this study

This is a 2x2, within-subjects, cross-over trial to test the anti-depressant effects of acute exercise in 20 participants with bipolar depression. Participants will complete four experimental sessions, two with an exercise challenge and two with a resting control condition in a counterbalanced order. Participants will receive either 800mg of ibuprofen or placebo before exercise or rest in order to test whether blocking the inflammatory response to exercise interferes with the neural and psychological effects of exercise.

This description comes directly from the study's public registry record.

Talk to the study team

Jonathan Savitz  ·  9185025104  ·  jsavitz@laureateinstitute.org

Always discuss trial participation with your own doctor first.

Locations (1)

Laureate Institute for Brain ResearchTulsa, Oklahoma, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06088732