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Study identifier: NCT06088602 Synced from ClinicalTrials.gov · July 28, 2026
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Cryoneurolysis for Acute Postoperative Pain Following Total Knee Arthroplasty

Condition: Acute Postoperative Pain  ·  Sponsor: Copenhagen University Hospital, Hvidovre

PhaseNA
Planned participants44
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Cryoneurolysis is a regional anaesthetic technique that works by freezing peripheral sensory nerves. This technique can potentially provide analgesia after total knee arthroplasty (TKA). However, the technique is expensive and comprehensive. Pain 24 hours after surgery is associated with high amounts of late acute pain. Therefore, the aim of the current study was to compare the effect of postoperative cryoanalgesia with a sham treatment on acute postoperative pain in TKA patients with moderate to severe pain on the first postoperative day. The cryoanalgesia treatment will be performed 24 hours after surgery. Afterward, the patients will be followed for 24 weeks to determine the level of pain among other outcomes.

This description comes directly from the study's public registry record.

Talk to the study team

Anders H Springborg, MD  ·  26815919  ·  andersspringborg@gmail.com

Nicolai B Foss, dr.med.  ·  38625328  ·  nicolai.bang.foss@regionh.dk

Always discuss trial participation with your own doctor first.

Locations (1)

Hvidovre HospitalHvidovre, DenmarkRecruiting

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Source record: clinicaltrials.gov/study/NCT06088602