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Study identifier: NCT06086457 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

PD-1 Inhibitor Plus Chemotherapy With or Without Radiotherapy in Patients With Metastatic Esophageal Cancer

Condition: Esophageal Neoplasms  ·  Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

PhasePhase 3
Planned participants436
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The treatment efficacy for stage IVb esophageal cancer has been improved through chemotherapy combined with immunotherapy recently. On this basis, the investigators intend to conduct a prospective, multicenter phase III clinical trial to assess whether radiotherapy with concurrent chemotherapy and immunotherapy could further improve the survival of patients with metastatic esophageal cancer. Accompanied tissue samples, blood samples and urine samples will be analyzed by molecular biological detection (Including Whole Exome Sequencing and proteomics) to explore potential biomarkers for predicting outcomes, efficacy and toxicity.

This description comes directly from the study's public registry record.

Talk to the study team

Wen-Yang Liu, MD  ·  8601087787625  ·  liuwenyang@cicams.ac.cn

Zhi-Hao Lu, MD  ·  86-10-88196561  ·  pppeirain@126.com

Always discuss trial participation with your own doctor first.

Locations (1)

Cancer hospital, CAMSBeijing, Beijing Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06086457