Condition: Carcinoma, Hepatocellular · Liver Cancer · Liver Cirrhosis · Sponsor: University of Texas Southwestern Medical Center
The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using semi-annual ultrasound and AFP-based screening or Arm B using semi-annual screening using GALAD alone. Randomization will be stratified by sex, enrolling site, Child Pugh class (A vs. B), and HCC etiology (viral vs. non-viral). Patients will be recruited from 15 sites (mix of tertiary care and large community health systems) over a 3-year period, and the primary endpoint of the phase IV trial, reduction in late-stage HCC, will be assessed after 5.5 years.
This description comes directly from the study's public registry record.
Amit Singal, MD, MS · 214.645.8821 · Amit.Singal@UTSouthwestern.edu
Sneha Deodhar, MS · 214.645.1378 · Sneha.Deodhar@UTSouthwestern.edu
Always discuss trial participation with your own doctor first.
| University of Southern California | Los Angeles, California, United States | Recruiting |
| Stanford University | Redwood City, California, United States | Recruiting |
| Kaiser Permanente | Roseville, California, United States | Recruiting |
| University of California, San Francisco | San Francisco, California, United States | Recruiting |
| Northwestern University | Chicago, Illinois, United States | Recruiting |
| Indiana University | Indianapolis, Indiana, United States | Recruiting |
| Massachusetts General Hospital | Boston, Massachusetts, United States | Recruiting |
| University of Michigan | Ann Arbor, Michigan, United States | Recruiting |
| Henry Ford Health System | Detroit, Michigan, United States | Recruiting |
| Hennepin Healthcare | Minneapolis, Minnesota, United States | Recruiting |
| University of Minnesota | Minneapolis, Minnesota, United States | Recruiting |
| The Feinstein Institutes, Northwell Health, Inc. | Manhasset, New York, United States | Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06084234