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Study identifier: NCT06083922 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) Plus Daratumumab in People With Monoclonal Gammopathy of Renal Significance (MGRS)

Condition: Multiple Myeloma · Monoclonal Gammopathy of Renal Significance  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to find out whether cyclophosphamide, bortezomib, dexamethasone (CyBorD) with daratumumab SC is a safe treatment combination for MGRS-associated kidney disease including cast nephropathy associated with multiple myeloma. In addition, the researchers will find out whether the study drug combination is an effective treatment for these conditions.

This description comes directly from the study's public registry record.

Talk to the study team

Hani Hassoun, MD  ·  646-608-3718  ·  hassounh@mskcc.org

Carlyn R Tan, MD  ·  646-608-3778

Always discuss trial participation with your own doctor first.

Locations (11)

Tufts Medical Center (Data Collection Only)Boston, Massachusetts, United StatesActive Not Recruiting
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer Center Suffolk - Commack (Limited Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison, New York, United StatesRecruiting
Weill Cornell Medical Center (Data Collection Only)New York, New York, United StatesNot Yet Recruiting
Mount Sinai Hospital (Data Collection Only)New York, New York, United StatesCompleted
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (Limited Protocol Activities)Uniondale, New York, United StatesRecruiting
University of North Carolina (Data Collection Only)Chapel Hill, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06083922