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Study identifier: NCT06077240 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

Condition: Smoking · Smoking Behaviors · Nicotine Dependence  ·  Sponsor: Yale University

PhaseNA
Planned participants256
Who can joinAll sexes, 21 Years to no upper limit
Healthy volunteersNo

About this study

The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible regulatory scenarios within products where flavor availability is either menthol and tobacco/unflavored available or tobacco/unflavored only available, and nicotine concentration is either higher (5% e-cig, 6mg pouch) or lower (2.4% e-cig, 3mg pouch). Participants will return for bi-weekly research visits (in person or remote videocall) to complete measures for study aims. Participants will complete a final follow-up at Week 6 to assess maintenance of cigarette reduction and willingness to continue using products once they are no longer provided. The investigators expect to observe which products and constituents lead to greater smoking reduction.

This description comes directly from the study's public registry record.

Talk to the study team

Lisa M. Fucito, PhD  ·  203-200-1470  ·  lisa.fucito@yale.edu

Krysten W Bold, PhD  ·  203-974-7603  ·  krysten.bold@yale.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Yale UniversityNew Haven, Connecticut, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06077240