Condition: Liver Transplant · Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
This is a multi-center clinical trial in Cytomegalovirus (CMV) seronegative prospective liver transplant recipients to determine the efficacy of two doses of Cytomegalovirus-Modified Vaccinia Ankara (CMV-MVA) Triplex CMV vaccine pre-transplant. The primary objective is to assess the effect of pre-transplant (Tx) Triplex vaccination on duration of CMV antiviral therapy (AVT) within the first 100 days post-Tx in CMV seropositive donor (D+) and seronegative (R-) (D+R-) liver transplant recipients (LTxRs). A protocol-mandated preemptive therapy (PET) will be used for CMV disease prevention in D+R- LTxRs.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| University of Alabama at Birmingham, School of Medicine | Birmingham, Alabama, United States | Withdrawn |
| University of California, San Diego School of Medicine | La Jolla, California, United States | Recruiting |
| Stanford University | Redwood City, California, United States | Recruiting |
| University of California, San Francisco | San Francisco, California, United States | Recruiting |
| University of Miami, Jackson Memorial Hospital | Miami, Florida, United States | Recruiting |
| Emory University Hospital | Atlanta, Georgia, United States | Recruiting |
| Northwestern University, Feinberg School of Medicine | Chicago, Illinois, United States | Recruiting |
| Johns Hopkins University School of Medicine | Baltimore, Maryland, United States | Recruiting |
| University of Michigan Medical Center | Ann Arbor, Michigan, United States | Recruiting |
| Mayo Clinic, Rochester - College of Medicine and Science | Rochester, Minnesota, United States | Recruiting |
| University of Nebraska Medical Center | Omaha, Nebraska, United States | Recruiting |
| Duke University School of Medicine | Durham, North Carolina, United States | Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06075745