Condition: Perinatal Depression · PerinatalAnxiety · Sponsor: The Canadian College of Naturopathic Medicine
Perinatal depression and anxiety (PDA) are the leading causes of maternal mortality in developed countries. Women with a history of depression have a 20 fold higher risk of PDA at subsequent pregnancies. The adverse outcomes extend beyond maternal well-being to long-term deficits in children and families. The gut-brain axis is a newly recognized key player in mental health disorders. Specifically, the microbial composition of the gut along with their metabolites are directly involved in disease onset and course. Recent clinical studies have identified diet as the most powerful environmental factor in manipulating gut microbiome. Given vulnerability and resistance of pregnant women to pharmacotherapy, particularly in those with a predisposition to mood disorders, as well as pregnant women's high motivation and commitment to improving gestational diet, a dietary/supplemental intervention to 'optimize' gut microbiome, is a favored approach in disease management. The study investigators aim to exploit microbial responsiveness to diet together with this maternal motivation, to alter the risk and severity of a universal public health concern that has dire and long-term consequences for new moms and their children. The investigators of this trial, will first study the challenges in pursuing a study aimed at changing the microbiome of pregnant women with a history of mood disorders. Pregnant women in their second trimester will be recruited. Each will be assigned or randomized to on…
This description comes directly from the study's public registry record.
Neda Ebrahimi, PhD · 416-498-1255 · nebrahimi@ccnm.edu
Sophie Grigoriadis, MD · 416-480-5677 · sophie.grigoriadis@sunnybrook.ca
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| Sunnybrook Health Science Center | Toronto, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06074250