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Study identifier: NCT06073431 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

Condition: Advanced Colorectal Carcinoma · Advanced Lung Non-Small Cell Carcinoma · Advanced Pancreatic Adenocarcinoma  ·  Sponsor: University of Rochester

PhaseN/A
Planned participants800
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable) or is stage IV. Patients with these cancer types are at risk for developing cancer cachexia (CC), which is defined as weight loss, muscle loss, and fat loss due to cancer. CC has been associated with reduced physical performance, impaired quality of life, and poorer survival. Many studies that have evaluated treatments for cancer-related weight and muscle loss have aimed to treat all patients with weight loss exactly the same and, unfortunately, have not been successful. Like different cancer types, weight and muscle loss related to cancer may have different causes in different individuals and the best treatment strategy for this condition may not be a one-size-fits-all approach. Information gathered from this study may help researchers develop new diagnostic criteria for CC and design better treatments and clinical trials for cancer-related weight and muscle loss in the future to improve the quality of life in patients with advanced colorectal, lung, or pancreatic cancer.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (225)

Mercy Hospital Fort SmithFort Smith, Arkansas, United StatesRecruiting
Rocky Mountain Cancer Centers-AuroraAurora, Colorado, United StatesActive Not Recruiting
Boulder Community Foothills HospitalBoulder, Colorado, United StatesActive Not Recruiting
Rocky Mountain Cancer Centers-BoulderBoulder, Colorado, United StatesActive Not Recruiting
Rocky Mountain Cancer Centers - CentennialCentennial, Colorado, United StatesActive Not Recruiting
The Women's Imaging CenterDenver, Colorado, United StatesActive Not Recruiting
Colorado Blood Cancer InstituteDenver, Colorado, United StatesActive Not Recruiting
Rocky Mountain Cancer Centers-MidtownDenver, Colorado, United StatesActive Not Recruiting
Rocky Mountain Cancer Centers-RoseDenver, Colorado, United StatesActive Not Recruiting
Rocky Mountain Cancer Centers - SwedishEnglewood, Colorado, United StatesActive Not Recruiting
The Melanoma and Skin Cancer InstituteEnglewood, Colorado, United StatesActive Not Recruiting
Rocky Mountain Cancer Centers-LakewoodLakewood, Colorado, United StatesActive Not Recruiting

+ 213 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06073431