Condition: Advanced Solid Tumor · Sponsor: Shanghai East Hospital
This is an open-label, dose escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of autologous B4T2-001 CAR-T in subjects with advanced solid tumors including but not limited to advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma, advanced pancreatic cancer, advanced non-small cell lung cancer (NSCLC), colorectal cancers (CRC) and metastatic breast cancer that tests positive for BT-001 target antigen according to Immunohistochemistry (IHC). The trial builds off first-in-human results from pilot study per clinicaltrials.gov ID: NCT05621486 to administer multiple infusions of B4T2-001 CAR-T without the need to give preparative chemotherapy (lymphodepletion).
This description comes directly from the study's public registry record.
Jin Li, MD,PhD · +86-13761222111 · lijin@csco.org.cn
Always discuss trial participation with your own doctor first.
| Shanghai East Hospital | Shanghai, China/Shanghai, China | Recruiting |
| Shanghai Artemed Hospital | Shanghai, China/Shanghai, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06072989