Condition: Adolescent Depression · Sponsor: University of North Carolina, Chapel Hill
Starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention deficit hyperactivity disorder (ADHD). This divergence between the sexes during puberty suggests sex-specific pathways of risk and differential effects of sex hormones. The purpose of this research is to determine: 1) sex-specific neural and endocrine features of the pubertal transition that may mediate sex differences in adolescent mood disorders, and 2) the neurophysiological basis of susceptibility to hormone change during puberty.
This description comes directly from the study's public registry record.
Kayla Jensen, BS · 919-445-6815 · nerdlab@unc.edu
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Source record: clinicaltrials.gov/study/NCT06072677