Condition: Lung Function · BPD - Bronchopulmonary Dysplasia · Sponsor: Children's Hospital of Eastern Ontario
Bronchopulmonary dysplasia (BPD) is a common, major complication of premature birth, associated with developmental and health consequences that continue into adulthood. Prediction of who will have these problems is challenging using traditional definitions of disease. It is believed that underdevelopment and injury occur in both lung tissue and the blood vessels in the lungs, with a sophisticated interplay between them that contributes to lung disease seen in prematurity. New magnetic resonance imaging (MRI) techniques can delineate tissue structure with unprecedented granularity, assessing lung tissue, blood vessels, and their interplay. The ability to identify, at an early stage, those infants destined for chronic lung disease with greater certainty will be useful in counseling families and critical for the effective introduction of promising new BPD therapies. 319 infants born less than 29 weeks gestation will be recruited from 4 centres, including 5 babies who received stem cell therapy in a clinical trial. Babies will be evaluated at 36 weeks post-conception with lung MRI, oscillometry (lung function), echocardiogram (heart ultrasound), and oscillometry. Lung health will be assessed every 3 months by phone questionnaire and chart review. At 18-21 months post-conception, babies will undergo neurodevelopmental assessment and lung function testing. The investigators will look at how well baseline MRI markers predict subsequent lung health and development, independently and …
This description comes directly from the study's public registry record.
Sherri Katz · (613) 737-7600 · skatz@cheo.on.ca
Always discuss trial participation with your own doctor first.
| The Children's Hospital of Eastern Ontario | Ottawa, Ontario, Canada | Recruiting |
| Mount Sinai Hospital | Toronto, Ontario, Canada | Recruiting |
| CHU-Sainte Justine | Montreal, Quebec, Canada | Active Not Recruiting |
| Montreal Children's Hospital | Montreal, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06065215