Condition: Frontotemporal Dementia · FTD · FTD-GRN · Sponsor: AviadoBio Ltd
The goal of this clinical study is to learn about an investigational gene therapy product called AVB-101, which is designed to treat a disease called Frontotemporal Dementia with Progranulin Mutations (FTD-GRN). FTD-GRN is an early-onset form of dementia, a progressive brain disorder that affects behavior, language and movement. These symptoms result from below normal levels of a protein called progranulin (PGRN) in the brain, which leads to the death of nerve cells (neurons), affecting the brain's ability to function. The main questions that the study aims to answer are: 1. Is a one-time treatment with AVB-101 safe for patients with FTD-GRN? 2. Does a one-time treatment with AVB-101 restore PGRN levels to at least normal levels? 3. Could AVB-101 work as a treatment to slow down or stop progression of FTD-GRN? In this study there is no placebo (a dummy pill or treatment used for comparison purposes), so all participants will receive a one-time treatment of AVB-101 delivered directly to the brain, with follow-up assessments for 5 years.
This description comes directly from the study's public registry record.
AviadoBio Clinical Trials · +44 203-089-7917 · clinicaltrials@aviadobio.com
Always discuss trial participation with your own doctor first.
| The Ohio State University (OSU) Wexner Medical Center | Columbus, Ohio, United States | Recruiting |
| Vanderbilt University Medical Centre | Nashville, Tennessee, United States | Recruiting |
| Houston Methodist Hospital | Houston, Texas, United States | Recruiting |
| UZ Leuven | Leuven, Belgium | Recruiting |
| Sunnybrook Health Sciences Centre | Toronto, Ontario, Canada | Recruiting |
| Fondazione IRCCS Istituto Neurologico Carlo Besta | Milan, Italy | Recruiting |
| Amsterdam UMC | Amsterdam, Netherlands | Recruiting |
| NEURO-CARE Sp. z o.o. Sp. Komandytowa | Katowice, Poland | Recruiting |
| Neurologia Slaska Centrum Medyczne | Katowice, Poland | Recruiting |
| Uniwersyteckie Centrum Kliniczne, SUM w Katowicach | Katowice, Poland | Recruiting |
| Euromedis Sp. z o.o. | Szczecin, Poland | Recruiting |
| Centrum Medyczne NeuroProtect Sp z o.o. | Warsaw, Poland | Recruiting |
+ 7 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06064890