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Study identifier: NCT06062498 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Elacestrant vs Elacestrant Plus a CDK4/6 Inhibitor in Patients With ERpositive/HER2-negative Advanced or Metastatic Breast Cancer

Condition: Estrogen-receptor-positive Breast Cancer · HER2/Neu-Negative Breast Cancer · Advanced Breast Cancerv  ·  Sponsor: Northwestern University

PhasePhase 2
Planned participants174
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Breast cancer is not only the leading cause of cancer in women, but also the leading cause of cancer deaths in women. Estrogen receptor-positive and HER2-negative breast cancer is the most prevalent breast cancer subtype. Endocrine therapy is the mainstay of treatment; however, due to the varied nature of the disease, development of resistance to this therapeutic approach is very common in the metastatic setting. The purpose of this study is to see whether the effectiveness of elacestrant can be enhanced by combining it with a targeted agent such as a CDK4/6 inhibitor to treat patients with ER+/HER2- or metastatic breast cancer with prior exposure to a CDK4/6 inhibitor.

This description comes directly from the study's public registry record.

Talk to the study team

Study Coordinator  ·  3126951301  ·  cancer@northwestern.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Northwestern UniversityChicago, Illinois, United StatesRecruiting
Rush University Medical CenterChicago, Illinois, United StatesNot Yet Recruiting
University of ChicagoChicago, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06062498