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Study identifier: NCT06059313 Synced from ClinicalTrials.gov · July 28, 2026
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Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Condition: Behavioral Variant of Frontotemporal Disorder (bvFTD) · Phenocopy Frontotemporal Dementia (phFTD) · Frontal Variant of Alzheimer Disease  ·  Sponsor: Nantes University Hospital

PhaseN/A
Planned participants120
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility. The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.

This description comes directly from the study's public registry record.

Talk to the study team

Claire BOUTOLEAU-BRETONNIERE, PH  ·  33 2 40 16 54 22  ·  claire.boutoleaubretonniere@chu-nantes.fr

Laetitia BARBIN  ·  33 2 40 16 59 42  ·  laetitia.barbin@chu-nantes.fr

Always discuss trial participation with your own doctor first.

Locations (1)

CHU de NantesNantes, FranceRecruiting

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Source record: clinicaltrials.gov/study/NCT06059313