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Study identifier: NCT06054477 Synced from ClinicalTrials.gov · July 29, 2026
● Terminated

Study of ALE.C04 in Patients With Head and Neck Cancer

Condition: Head and Neck Cancer · Head and Neck Squamous Cell Carcinoma  ·  Sponsor: Alentis Therapeutics AG

PhasePhase 1/Phase 2
Planned participants21
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety profile of ALE.C04 monotherapy and in combination with pembrolizumab, to characterize pharmacokinetics profile of ALE.C04, recommended Phase II dose (RP2D) for ALE.C04 in combination with pembrolizumab and to assess anti-tumor activity of ALE.C04 in combination with pembrolizumab in patients with Head and Neck Cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (22)

Banner MD Anderson Cancer CenterGilbert, Arizona, United States
University of Southern California USC Norris Comprehensive Cancer CenterLos Angeles, California, United States
Yale University Yale Cancer CenterNew Haven, Connecticut, United States
Massachusetts General HospitalBoston, Massachusetts, United States
Karmanos Cancer InstituteDetroit, Michigan, United States
Washington University School of MedicineLake Saint Louis, Missouri, United States
Gabrail Cancer Center ResearchCanton, Ohio, United States
University Health Network, Princess Margaret Cancer CentreToronto, Ontario, Canada
Centre Hospitalier Universitaire (CHU) de Bordeaux - Hospitalier Saint-AndreBordeaux, France
Oncopole Claudius Regaud, Iuct-OncopoleToulouse, France
Institut Gustave RoussyVillejuif, France
Prince Of Wales HospitalHong Kong, Hong Kong

+ 10 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06054477