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Study identifier: NCT06051409 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ ALL (POLARIS-1)

Condition: Ph+ ALL · Leukemia, Lymphoblastic, Acute, Philadelphia-Positive  ·  Sponsor: Ascentage Pharma Group Inc.

PhasePhase 3
Planned participants350
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A global multicenter, open-label, randomized and registrational Phase 3 study to evaluate efficacy and safety of olverembatinib combined with chemotherapy versus investigator's choice of tyrosine kinase inhibitor (TKI) combined with chemotherapy in subjects with newly-diagnosed Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL).

This description comes directly from the study's public registry record.

Talk to the study team

Ascentage Clinical Operations  ·  301-291-5658  ·  clinical-trials@ascentage.com

Always discuss trial participation with your own doctor first.

Locations (90)

Ascentage Investigative Site #1044Birmingham, Alabama, United StatesNot Yet Recruiting
Ascentage Investigative Site #1062Duarte, California, United StatesNot Yet Recruiting
Ascentage Investigative Site #1134Los Angeles, California, United StatesNot Yet Recruiting
Ascentage Investigative Site #1059Los Angeles, California, United StatesNot Yet Recruiting
Ascentage Investigative Site #1142Miami, Florida, United StatesNot Yet Recruiting
Ascentage Investigative Site #1045Augusta, Georgia, United StatesNot Yet Recruiting
Ascentage Investigative Site #1158Indianapolis, Indiana, United StatesNot Yet Recruiting
Ascentage Investigative Site #1069Indianapolis, Indiana, United StatesNot Yet Recruiting
Ascentage Investigative Site #1084Lexington, Kentucky, United StatesNot Yet Recruiting
Ascentage Investigative Site #1064Hackensack, New Jersey, United StatesNot Yet Recruiting
Ascentage Investigative Site #1098New Brunswick, New Jersey, United StatesNot Yet Recruiting
Ascentage Investigative Site #1160Stony Brook, New York, United StatesNot Yet Recruiting

+ 78 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06051409