Condition: Resectable Intrahepatic Cholangiocarcinoma · Sponsor: National Cancer Institute (NCI)
This phase II trial tests how well giving durvalumab with standard chemotherapy, gemcitabine and cisplatin, before surgery works in treating patients with high risk liver cancer (cholangiocarcinoma) that can be removed by surgery (resectable). Durvalumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving durvalumab with gemcitabine and cisplatin before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed in patients with high risk resectable cholangiocarcinoma.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine, California, United States | Recruiting |
| Los Angeles General Medical Center | Los Angeles, California, United States | Active Not Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, United States | Recruiting |
| UCHealth University of Colorado Hospital | Aurora, Colorado, United States | Recruiting |
| Smilow Cancer Hospital-Derby Care Center | Derby, Connecticut, United States | Recruiting |
| Smilow Cancer Hospital Care Center-Fairfield | Fairfield, Connecticut, United States | Recruiting |
| Smilow Cancer Hospital Care Center at Glastonbury | Glastonbury, Connecticut, United States | Recruiting |
| Smilow Cancer Hospital Care Center at Greenwich | Greenwich, Connecticut, United States | Recruiting |
| Smilow Cancer Hospital Care Center - Guilford | Guilford, Connecticut, United States | Recruiting |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford, Connecticut, United States | Recruiting |
| Yale University | New Haven, Connecticut, United States | Recruiting |
| Yale-New Haven Hospital North Haven Medical Center | North Haven, Connecticut, United States | Recruiting |
+ 46 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06050252