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Study identifier: NCT06046859 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Can Immediate Post-injury Fluoxetine Improve the Recovery Trajectories of Victims in Bodily Trauma?

Condition: Musculoskeletal Injury  ·  Sponsor: University of Florida

PhasePhase 4
Planned participants200
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

With this prospective double-blinded, placebo controlled clinical trial we hypothesize that immediate (post-injury) intervention with Fluoxetine will prevent/mitigate the development of negative psychiatric symptomology such as PTSD and depression for victims of bodily trauma. We also hypothesize that immediate use of Fluoxetine will decrease subjects' pain, pain interference and opioid use without changing our standard of care post-injury pain medication regimen. Enrolled subjects will be randomized to Fluoxetine or placebo at their index hospitalization.

This description comes directly from the study's public registry record.

Talk to the study team

Jennifer Hagen, MD  ·  352-273-7016  ·  hagenje@ortho.ufl.edu

MaryBeth Horodyski, EdD  ·  352-273-7074  ·  horodmb@ortho.ufl.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of FloridaGainesville, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06046859