Condition: Psychotic Disorders · Autism Spectrum Disorder · Major Depressive Disorder · Sponsor: Centre Hospitalier St Anne
The goal of this observational study is to compare subjects with at-risk-mental-state, early psychosis, schizophrenia, depression, and autism spectrum disorders, with healthy controls (N = 21 x 6). The main questions it aims to answer are: * are EEG microstate anomalies associated with diagnosis, clinical and functional prognosis, both in resting conditions and during sleep ? * are EEG microstates anomalies associated with differences in sensorimotor integration, prosodic and conversational, interoceptive, and narrative self ? * an ancillary study will be to see whether in healthy controls EEG microstate properties vary under light hypnosis conditions. Participants will: * undergo deep phenotyping based on psychopathology and neuropsychological assessments * undergo a high-resolution EEG (64 electrodes) with a resting period and a sensorimotor task; and healthy controls will have a light hypnosis period. * undergo a recording of the characteristics of their voice (tone, prosody) * undergo a one-night polysomnography * undergo MRI and biological sampling for multi-omic analyses * undergo a virtual reality experience
This description comes directly from the study's public registry record.
Anton Iftimovici, MD, PhD · 0033(0)145658179 · anton.iftimovici@ghu-paris.fr
Valeria Lucarini, MD, MS · 0033(0)145658179 · valeria.lucarini@ghu-paris.fr
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| Centre de Recherche Clinique, Hôpital Sainte-Anne, GHU Paris Psychiatrie et Neurosciences | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06045897