Condition: Cardiac Arrest · Sponsor: CMC Ambroise Paré
Despite advances in post-resuscitation care of patients with cardiac arrest (CA), the majority of survivors who are treated after restoration of spontaneous circulation (ROSC) will have sequelae of hypoxic-ischemic brain injury ranging from mild cognitive impairment to a vegetative state. Early prognostication in comatose patients after ROSC remains challenging. Recent recommendations suggest carrying out clinical and paraclinical tests during the first 72 h after ROSC, to predict a poor neurological outcome with a specificity greater than 95% (no pupillary and corneal reflexes, bilaterally absent N20 somatosensory evoked potential wave, status myoclonus, highly malignant electroencephalography including suppressed background ± periodic discharges or burst-suppression, neuron-specific enolase (NSE) \> 60 µg/L, a diffuse and extensive anoxic injury on brain CT/MRI), but with a low sensitivity due to frequent confounding factors. The heart rate variability (HRV) is a simple and non-invasive technique for assessing the autonomic nervous system function. In patients with a recent myocardial infarction, reduced HRV is associated with an increased risk for malignant arrhythmias or death. In neurology, reduced HRV is associated with a poor outcome in severe brain injury patients and allows to predict early neurological deterioration and recurrent ischemic stroke after acute ischemic stroke. A reduced HRV could be a sensitive, specific and early indicator of diffuse anoxic brain i…
This description comes directly from the study's public registry record.
Guillaume GERI, MD, PhD · 0146415079 · guillaume.geri@clinique-a-pare.fr
Cécile NAUDIN, PhD · cecile.naudin@clinique-a-pare.fr
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| Brest University Hospital | Brest, Brittany Region, France | Recruiting |
| Nantes University Hospital | Nantes, Pays de la Loire Region, France | Recruiting |
| Marseille University Hospital | Marseille, Provence-Alpes-Côte d'Azur Region, France | Recruiting |
| Ambroise Paré - Hartmann Private Hospital Group | Neuilly-sur-Seine, Île-de-France Region, France | Recruiting |
| Cochin Hospital | Paris, Île-de-France Region, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06044922