Condition: Spina Bifida · Sponsor: Rennes University Hospital
The aim of the study is to investigate known urinary biomarkers in order to determine whether they can be predictive of a risk of damage to the upper urinary tract and therefore the kidneys in patients with spina bifida. The risk of damage to the upper urinary tract can be calculated using the Galloway score, based on the results of the urodynamic study and retrograde urethrocystography, which all patients with spina bifida have regularly. The urinary biomarkers studied TIMP-2 (Tissue inhibitor of metalloproteinases 2) and MMP-2 (matrix metalloproteinase-2) are potentially associated with renal degradation, but this has not yet been demonstrated. Volunteers to take part in the study will have their biomarkers measured at the time of their urodynamic assessment.
This description comes directly from the study's public registry record.
LOÏC JACOB · 0299282555 · loic.jacob@chu-rennes.fr
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| Rennes University Hospital | Rennes, CHU de Rennes, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06041334