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Study identifier: NCT06040957 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Bone Marrow Versus Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis

Condition: Knee Osteoarthritis  ·  Sponsor: Istituto Ortopedico Rizzoli

PhaseNA
Planned participants204
Who can joinAll sexes, 40 Years to 75 Years
Healthy volunteersNo

About this study

The MAST-GR study is a randomized controlled interventional trial with parallel treatment arms and 1:1 allocation The primary objective of the study is to compare the safety and efficacy of a single intra-articular infiltration of Bone marrow aspirate concentrate (BMAC) with one of minimally manipulated adipose tissue (MM-AT) so as to determine the most effective cellular product in treating patients with knee osteoarthritis (OA). The secondary objective is to demonstrate whether intra-articular infiltration of BMAC or MM-AT can induce disease-modifying effects in knee OA by imaging and biological assessments on peripheral blood. The tertiary objective of the study is to identify factors that influence the clinical response to treatment (baseline characteristics of patients, biological characteristics of the treated knee, characteristics of cellular products, BMAC and MM-AT).

This description comes directly from the study's public registry record.

Talk to the study team

Luca Andriolo, MD  ·  6366567  ·  luca.andriolo@ior.it

Roberta Licciardi, MSc  ·  6366567  ·  roberta.licciardi@ior.it

Always discuss trial participation with your own doctor first.

Locations (1)

Istituto Ortopedico RizzoliBologna, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT06040957