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Study identifier: NCT06039709 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sonodynamic Therapy in Patients With Recurrent GBM

Condition: Recurrent Glioblastoma · Glioblastoma Multiforme · GBM  ·  Sponsor: Shayan Moosa, MD

PhasePhase 1
Planned participants11
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

Patients diagnosed with glioblastoma (GBM) are faced with limited treatment options. This pilot study will evaluate the safety and feasibility of combining an investigational drug called 5-ALA with neuronavigation-guided low-intensity focused ultrasound (LIFU) for patients who have recurrent GBM. Focused ultrasound (FUS) can be used to non-invasively destroy tumor tissue while preserving normal tissue. When FUS is combined with 5-ALA, this combinatorial approach is called sonodynamic therapy (SDT), and this investigational therapy is being tested for its ability to cause damage to GBM cells. SDT will take place prior to surgery for recurrent GBM.

This description comes directly from the study's public registry record.

Talk to the study team

Zachary Sturgill  ·  434-243-9986  ·  FFM7RC@uvahealth.org

Judith Beenhakker, M.S.  ·  434-982-1856  ·  jgb3p@uvahealth.org

Always discuss trial participation with your own doctor first.

Locations (1)

University of VirginiaCharlottesville, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06039709