Condition: Venoarterial Extracorporeal Membrane Oxygenation · Renal Replacement Therapy · Acute Kidney Injury · Sponsor: Hospices Civils de Lyon
Extracorporeal membrane oxygenation (ECMO) is an extra-corporeal assistance used in case of respiratory or circulatory failure. In case of circulatory failure, ECMO is in the veno-arterial configuration (VA-ECMO). VA-ECMO patients are at high risk of developing acute kidney injury (AKI) and renal replacement therapy (RRT) may be needed in 50% of ECMO patients. Although the administration of RRT in ECMO patients has major implications, no specific recommendations are currently available. The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) international conference identified the evaluation of RRT in these ECMO patients as a research priority. In 2023, the two main configurations used to administer RRT in ECMO patients are an independent delivery on a separate vascular access (parallel connection) or an integration of the RRT machine directly into the ECMO circuit (integrated connection). The integrated connection may reduce infectious and bleeding complications associated with the use of a second vascular access. However, it can expose the hemofilter and circuit to excessive positive pressures that can trigger pressure alarms in the RRT machine and expose the patient to a theoretical risk of air embolism or hemolysis. Furthermore, there is currently no robust data comparing the hemofilter lifespan with the parallel or with the integrated connection, although the filter lifespan is a crucial parameter to assess the quality of the RRT delivery in the ICU. The investigator…
This description comes directly from the study's public registry record.
Frank BIDAR, MD · (33) 472 116 942 · frank.bidar@chu-lyon.fr
Thomas RIMMELE, Professor MD · (33) 472 111 327 · thomas.rimmele@chu-lyon.fr
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| CHU de Bordeaux, GH Sud, Service d'anesthésie-réanimation cardiovasculaire, Hôpital cardiologique | Bordeaux, France | Recruiting |
| CHU de Clermont Ferrand, Pôle de médecine péri-opératoire/Chirurgie cardiaque, Hôpital Gabriel Montpied | Clermont-Ferrand, France | Recruiting |
| Centre Hospitalo Universitaire de Dijon, Unité Réanimation Cardio-Vasculaire, | Dijon, France | Recruiting |
| CHU de Grenoble, Service de réanimation cardiovasculaire et thoracique, Pôle anesthésie réanimation, Hôpital Nord | Grenoble, France | Recruiting |
| Centre Hospitalo Universitaire de Lille, Institut Coeur Poumon | Lille, France | Not Yet Recruiting |
| Hospices Civils de Lyon, Service d'Anesthésie-Réanimation cardiovasculaire, Hôpital Louis Pradel | Lyon, France | Recruiting |
| CHU de Montpellier, Département d'anesthésie-réanimation, Pôle Cœur-poumons, Hôpital Arnaud de Villeneuve | Montpellier, France | Recruiting |
| APHP, Institut de Cardiologie, Service d'anesthésie-réanimation cardiovasculaire, Hôpital de la Pitié-Salpêtrière | Paris, France | Recruiting |
| APHP, Institut de cardiologie, Service de Médecine Intensive Réanimation, Hôpital Pitié-Salpêtrière | Paris, France | Recruiting |
| CHU de Saint Etienne, Hôpital Bellevue, Service de Réanimation polyvalente et soins intensifs post-opératoires | Saint-Etienne, France | Recruiting |
| Centre Hospitalo Universitaire de Toulouse, Hôpital Rangueil - Réanimation polyvalente | Toulouse, France | Not Yet Recruiting |
| Centre Hospitalo Universitaire de Toulouse, Unité de Chirurgie Cardiaque | Toulouse, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06038162