Condition: Lung Transplant · Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
This is a trial in which 350 primary lung transplant recipients will be randomized (1:1) to receive either Tocilizumab (six doses over 20 weeks) plus standard triple maintenance immunosuppression or placebo (sterile normal saline) plus standard triple maintenance immunosuppression (Tacrolimus, Mycophenolate Mofetil, corticosteroids). The primary objective is to test the hypothesis that treatment with triple maintenance immunosuppression plus Tocilizumab (TCZ) is superior to triple maintenance immunosuppression plus placebo (saline) as defined by a composite endpoint of a) CLAD, b) listed for re-transplantation, and c) death
This description comes directly from the study's public registry record.
Yvonne Morrison, MS · 301-706-9137 · ymorrison@niaid.nih.gov
Always discuss trial participation with your own doctor first.
| St. Joseph's Hospital and Medical Center (Site #: 71192) | Phoenix, Arizona, United States | Recruiting |
| Cedars Sinai Medical Center (Site #: 71146) | Beverly Hills, California, United States | Recruiting |
| David Geffen School of Medicine at UCLA (Site #: 71123) | Los Angeles, California, United States | Recruiting |
| University of Florida Shands Hospital (Site #: 71131) | Gainesville, Florida, United States | Not Yet Recruiting |
| Emory University (Site #: 71103) | Atlanta, Georgia, United States | Not Yet Recruiting |
| University of Maryland Medical Center (Site #: 71138) | Baltimore, Maryland, United States | Withdrawn |
| Massachusetts General Hospital (Site #: 71107) | Boston, Massachusetts, United States | Recruiting |
| Boston Children's Hospital and Harvard Medical School (Site #: 71001) | Boston, Massachusetts, United States | Withdrawn |
| Mayo Clinic Rochester (Site #: 71160) | Rochester, Minnesota, United States | Not Yet Recruiting |
| Barnes Jewish Hospital/ Washington University SOM (Site #: 71191) | St Louis, Missouri, United States | Recruiting |
| St. Louis Children's Hospital of Washington University (Site #: 71006) | St Louis, Missouri, United States | Withdrawn |
| Columbia University Medical Center (Site #: 71113) | New York, New York, United States | Recruiting |
+ 9 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06033196