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Study identifier: NCT06033131 Synced from ClinicalTrials.gov · July 29, 2026
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PI4 - A Trial Assessing Metformin to Prolong Gestation in Preterm Preeclampsia

Condition: Preeclampsia  ·  Sponsor: Lina Bergman

PhasePhase 3
Planned participants294
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

Preterm preeclampsia is a severe condition for both the mother and the fetus. Currently, the only treatment available to stop disease progression is termination/delivery of the fetus and placenta. Therefore, preterm preeclampsia carries the highest rates of neonatal morbidity and mortality due to iatrogenic preterm birth. There is evidence suggesting metformin, a drug commonly used to treat diabetes in and outside pregnancy, may be able to counter the pathophysiology of preeclampsia, raising the possibility that it could be used to treat the condition. This multi centre double blind randomised controlled trial aims to investigate if metformin can prolong gestation, lower neonatal length of stay and increase birthweight in a Nordic setting.

This description comes directly from the study's public registry record.

Talk to the study team

Lina Bergman, Associate Professor  ·  0046-3134307  ·  lina.bergman@obgyn.gu.se

Pia Gudmundsson, PhD  ·  0046-313434327  ·  pia.gudmundsson@obgyn.gu.se

Always discuss trial participation with your own doctor first.

Locations (17)

Helsinki University HospitalHelsinki, FinlandNot Yet Recruiting
Tampere University HospitalTampere, FinlandRecruiting
Akershus University HospitalLørenskog, NorwayNot Yet Recruiting
Oslo University HospitalOslo, NorwayRecruiting
Södra Älvsborgs HospitalBorås, SwedenRecruiting
Falu LasarettFalun, SwedenRecruiting
Sahlgrenska University HospitalGothenburg, SwedenRecruiting
Linköping University HospitalLinköping, SwedenRecruiting
Skåne University HospitalLund, SwedenRecruiting
Skåne University HospitalMalmö, SwedenRecruiting
Karolinska University Hospital HuddingeStockholm, SwedenRecruiting
Karolinska University Hospital SolnaStockholm, SwedenRecruiting

+ 5 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06033131