Condition: Recurrent Lung Non-Small Cell Carcinoma · Stage IV Lung Cancer AJCC v8 · Sponsor: SWOG Cancer Research Network
This phase II Expanded Lung-MAP treatment trial tests tepotinib with or without ramucirumab for the treatment of patients with advanced non-small cell lung cancer that has spread from where it first started (primary site) to other places in the body (stage IV) or that has come back after a period of improvement (recurrent). Tepotinib is used in patients whose cancer has a mutated (changed) form of a gene called MET. It is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal MET protein that signals tumor cells to multiply. This helps slow or stop the spread of tumor cells. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Giving tepotinib with ramucirumab may lower the chance of the cancer from growing or spreading in patients with stage IV or recurrent non-small cell lung cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis | Daphne, Alabama, United States | Recruiting |
| Thomas Hospital | Fairhope, Alabama, United States | Recruiting |
| Mobile Infirmary Medical Center | Mobile, Alabama, United States | Recruiting |
| Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland | Saraland, Alabama, United States | Recruiting |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro, Arkansas, United States | Recruiting |
| University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States | Recruiting |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | Active Not Recruiting |
| Sutter Auburn Faith Hospital | Auburn, California, United States | Recruiting |
| Kaiser Permanente-Baldwin Park | Baldwin Park, California, United States | Active Not Recruiting |
| Kaiser Permanente-Bellflower | Bellflower, California, United States | Active Not Recruiting |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California, United States | Recruiting |
| Tower Cancer Research Foundation | Beverly Hills, California, United States | Recruiting |
+ 254 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06031688