Condition: Chronic Pain · Back Pain · Neck Pain · Sponsor: Stanford University
The goal of this clinical trial is to learn whether a combined behavioral and pharmacologic intervention can help reduce opioid use, improve pain recovery, and prevent opioid misuse after surgery in adults undergoing elective surgery. The study includes adults aged 18 to 75 who have a history of long-term opioid use, defined as having access to opioids for 60 or more days within the 180 days before surgery. The main questions it aims to answer are: * Does Motivational Interviewing with guided opioid tapering plus tizanidine (MI-Opioid Taper + Tizanidine) help participants return to their preoperative opioid use level or stop opioids faster than Enhanced Usual Care (EUC)? * Does the intervention reduce the time to pain resolution and decrease the likelihood of opioid misuse after surgery compared to EUC? Researchers will compare MI-Opioid Taper + Tizanidine to MI-Opioid Taper with placebo and to EUC to see whether the intervention improves postoperative opioid and pain outcomes. Participants will: * Complete a phone assessment and baseline survey before surgery * Be randomly assigned 7-13 days after surgery to one of three groups: * MI-Opioid Taper + tizanidine (MTT) * MI-Opioid Taper + placebo (MTP) * Enhanced Usual Care (EUC) * Complete brief weekly phone or video visits with a study clinician for 6 weeks starting 14 days after surgery * Take a study medication (tizanidine or placebo) three times daily for 5 weeks (MTT and MTP groups only) * Complete weekly onlin…
This description comes directly from the study's public registry record.
Shana C Levine, BA, CARES RESEARCH COORDINATOR · 650-649-9618 · Shana8@stanford.edu
SPARKLE (Strategies for Pain Alleviation though Research and Knowledge for Long-term Efficacy) Lab · CARESStudy@Stanford.edu
Always discuss trial participation with your own doctor first.
| Stanford University Medical Center | Stanford, California, United States | Recruiting |
| University of Kansas Medical Center | Kansas City, Kansas, United States | Recruiting |
| Harvard University- Brigham and Women's Hospital | Boston, Massachusetts, United States | Recruiting |
| Atrium Health Wake Forest Baptist Medical Center | Winston-Salem, North Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06027099