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Study identifier: NCT06025747 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 1 Study of Neoadjuvant Abemaciclib in Combination With Radiation Therapy for Liposarcomas

Condition: Retroperitoneal Sarcoma · Liposarcoma · Dedifferentiated Liposarcoma  ·  Sponsor: University of Washington

PhasePhase 1
Planned participants18
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase I trial tests the safety, side effects, and best dose of abemaciclib and how well it works with radiation therapy before surgery in treating patients with high-risk adipocytic retroperitoneal sarcoma. Abemaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving abemaciclib together with radiation therapy before surgery may shrink tumors in patients with high-risk adipocytic retroperitoneal sarcoma.

This description comes directly from the study's public registry record.

Talk to the study team

David Siu  ·  206-606-2465  ·  dsiu@fredhutch.org

Always discuss trial participation with your own doctor first.

Locations (1)

Fred Hutch/University of Washington Cancer ConsortiumSeattle, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06025747