Condition: Myeloproliferative Neoplasm · Sponsor: University Hospital, Bordeaux
Myeloproliferative Neoplasms (MPN) are hematological malignancies characterized by the excessive production of myeloid cells. MPN can be complicated by thrombosis and evolution into more aggressive diseases (myelofibrosis and acute leukemia). Aging remains the principal factor determining patients' survival in MPN. In recent years, DNA methylation has appeared as a mean to measure aging via the development of epigenetic clocks that have also been associated with the occurrence of thrombosis and cancer. The epiC project aims at determining epigenetic age of MPN patients and search for an association between this parameter and thrombotic/hematological complications.
This description comes directly from the study's public registry record.
Olivier MANSIER · olivier.mansier@chu-bordeaux.fr
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| CHU de Bordeaux, service Hématologie Biologique | Bordeaux, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06022328