Condition: Bronchiolitis Obliterans Syndrome · Chronic Lung Allograft Dysfunction · Lung Transplantation · Sponsor: Steven Hays, MD
The goal of this clinical trial is to learn about the safety and effectiveness of LAM-001 in patients who have developed bronchiolitis obliterans syndrome (BOS), a form of chronic rejection, after lung transplantation. The main questions it aims to answer are: * Is LAM-001 safe in these patients? * Is LAM-001 effective in slowing BOS progression? Participants will: * Be randomly assigned to inhale either LAM-001 or placebo (a look-alike substance that contains no active drug) daily for 48 weeks * Attend 10 study visits (mixture of in-person and telehealth) over the 48 week period * Undergo pulmonary function testing, bronchoscopy, lab testing, and physical examination * Submit weekly home spirometry monitoring Researchers will compare participants assigned to LAM-001 versus placebo to see if LAM-001 is safely tolerated and to assess the effectiveness of LAM-001 on slowing BOS progression.
This description comes directly from the study's public registry record.
Steven Hays, MD · 415-336-4141 · steven.hays@ucsf.edu
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| University of California, San Francisco | San Francisco, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06018766