Condition: Diastolic Heart Failure · Heart Failure With Preserved Ejection Fraction · Sponsor: Beth Israel Deaconess Medical Center
There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic response to stress. Loss of estrogen functionality in post menopausal women may account for the increased risk of diastolic heart failure. The investigators will explore said pathways using cardiac tissue obtained from patients undergoing cardiac surgery.
This description comes directly from the study's public registry record.
Robina Matyal, MD · 6176401208 · rmatyal1@bidmc.harvard.edu
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| Beth Israel Deaconess Medical Center | Boston, Massachusetts, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06015776