Condition: Asthma Acute · Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Asthma is a common chronic bronchial disease affecting 300 million people worldwide. The disease can be severe when it is not managed properly or when it is not controlled by treatments. Asthma is characterized by bronchial inflammation, bronchial hyperreactivity and tissue remodeling. Symptoms include episodes of coughing, dyspnoea and wheezing in relation with bronchial obstruction. The evolution is marked by the occurrence of exacerbations (increase of symptoms), most often triggered by viral infections, mostly due to rhinoviruses. The treatment of asthma is based on inhaled corticosteroid therapy sometimes combined with other treatments that help control the majority of asthma. However, about 10% of patients suffer from persistent symptoms despite these treatments. Natural killer (NK) cells are important actors of the antiviral innate immune response and are present in high numbers in the lungs. However, their role in severe asthma and its virus-induced exacerbations is unknown. The purpose of this work is to characterize NK cells in severe asthma in order to identify molecules expressed differently from control subjects. The goal is to assess whether these molecules could be potential biomarkers of a severe asthma subtype, also known as the endotype, and/or be the molecular control for exacerbation. The advantage of identifying biomarkers for inflammatory diseases lies in their usefulness in establishing a correct diagnosis, monitoring the progress of the disease and t…
This description comes directly from the study's public registry record.
Pascal Chanez, PU-PH · +334.91.96.58.64 · pascal.chanez@univ-amu.fr
Catherine Duez, CRCN · +334.91.32.42.74 · catherine.duez@inserm.fr
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| Hôpital NORD - AP-HM, Clinique des bronches, de l'allergie et du sommeil | Marseille, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06015256