Condition: Kidney Transplant · Chronic Kidney Disease · Sponsor: VA Office of Research and Development
Kidney transplantation improves the health and quality of life for those Veterans with end stage kidney disease (ESKD). While early patient and graft survival are excellent, long-term outcomes continue to be challenging. Patient death with existing kidney graft function occurs in about half of all recipients over time. This is primarily due to the development of cardiovascular disease in a patient population with multiple preexisting cardiac disease risk factors. There has been little progress in improving outcomes in this area for over two decades. Recent studies in chronic kidney disease (CKD) patients using SGLT2 inhibitors (SGLT2i), regardless of the presence of type 2 diabetes mellitus (T2DM), results in both kidney protective and cardiac protective impacts and improved patient outcomes. However, kidney transplant recipients (KTRs) were excluded from these clinical trials due to concerns that these agents promote infection, diminish graft function, and may alter immunosuppressive drug levels that are the mainstay of patient's transplant therapy. There are limited published data of SGLT2i treatment of selected KTRs.
This description comes directly from the study's public registry record.
Roslyn B Mannon, MD · (205) 999-7362 · roslyn.mannon@va.gov
Ramesh K Ramalingam · (402) 995-4873 · Ramesh.Ramalingam@va.gov
Always discuss trial participation with your own doctor first.
| Edward Hines Jr. VA Hospital, Hines, IL | Hines, Illinois, United States | Recruiting |
| Iowa City VA Health Care System, Iowa City, IA | Iowa City, Iowa, United States | Recruiting |
| Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE | Omaha, Nebraska, United States | Recruiting |
| VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA | Pittsburgh, Pennsylvania, United States | Recruiting |
| Tennessee Valley Healthcare System Nashville Campus, Nashville, TN | Nashville, Tennessee, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06013865