Condition: Post-exposure Prophylaxis · Sexually Transmitted Diseases · Doxycycline · Sponsor: Assistance Publique - Hôpitaux de Paris
Post-exposure prophylaxis (PEP) using doxycycline 200 mg within 24 hours of unprotected sexual intercourse to prevent sexually transmitted infections has demonstrated a reduction in the incidence of chlamydial and syphilis infections and syphilis infection by 70% and 73% in men who have sex with men (MSM) undergoing pre-exposure prophylaxis prophylaxis (PrEP) for HIV. Other studies are underway or in development on doxycycline prophylaxis for bacterial STIs, which are particularly common in this population. Monitoring adherence to PEP is of great interest in guaranteeing the effectiveness of this strategy and to be able to assess the uptake of PEP among PrEP users. Among the many methods for assessing adherence, measuring drug concentrations is a more accurate measure of adherence than self-reporting. The therapeutic monitoring of doxycycline and the assessment of adherence have been described using plasma and hair samples, allowing estimation of intake over the last 3-4 days and 4 months, respectively. Nevertheless, these biological matrices present several limitations for application in clinical practice: reflecting the duration of exposure should be more in line with the frequency of visits (2 months), and the collection of hair samples may be difficult due to refusal or short hair. On the other hand, interpretation of the hair assay is limited by the degradation of doxycycline in this matrix, which could lead to underestimation of drug intake. By Therefore, new biologica…
This description comes directly from the study's public registry record.
Lauriane GOLDWIRT, Dr · +33142494325 · lauriane.goldwirt@aphp.fr
Jérôme Lambert, Dr · +33142499742 · jerome.lambert@u-paris.fr
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| Hôpital Lariboisière AP-HP | Paris, France | Recruiting |
| Hôpital Saint Louis AP-HP | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06007534