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Study identifier: NCT06005493 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

Condition: Gastric Cancer · Gastro-esophageal Junction Cancer · Pancreatic Ductal Adenocarcinoma  ·  Sponsor: AstraZeneca

PhasePhase 1/Phase 2
Planned participants280
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research is designed to determine if experimental treatment with AZD5863, a T cell-engaging bispecific antibody that targets Claudin 18.2 (CLDN18.2) and CD3, is safe, tolerable and has anti-cancer activity in patients with advanced solid tumors.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (25)

Research SiteJacksonville, Florida, United StatesRecruiting
Research SiteRochester, Minnesota, United StatesRecruiting
Research SiteNew York, New York, United StatesWithdrawn
Research SiteBeijing, ChinaRecruiting
Research SiteBeijing, ChinaRecruiting
Research SiteShandong, ChinaRecruiting
Research SiteToulouse, FranceRecruiting
Research SiteVillejuif, FranceRecruiting
Research SiteChūōku, JapanRecruiting
Research SiteKashiwa, JapanRecruiting
Research SiteKōtoku, JapanRecruiting
Research SiteAmsterdam, NetherlandsRecruiting

+ 13 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06005493