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Study identifier: NCT06003387 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy in Adults With Hemophilia B With Pretreatment Adeno-associated Virus Serotype 5 (AAV5) Neutralizing Antibodies (Nabs)

Condition: Hemophilia B  ·  Sponsor: CSL Behring

PhasePhase 3
Planned participants35
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to assess the risk of bleeding due to failure of expected pharmacological action of CSL222 in adults with severe or moderately severe hemophilia B with detectable pretreatment AAV5 Nabs.

This description comes directly from the study's public registry record.

Talk to the study team

Trial Registration Coordinator  ·  1-610-878-4697  ·  clinicaltrials@cslbehring.com

Always discuss trial participation with your own doctor first.

Locations (30)

University of California, San Diego (UCSD)San Diego, California, United StatesRecruiting
University of MichiganAnn Arbor, Michigan, United StatesRecruiting
Hemophilia Center of Western Pennsylvania (HCWP)Pittsburgh, Pennsylvania, United StatesRecruiting
Royal Prince Alfred HospitalCamperdown, New South Wales, AustraliaRecruiting
Royal Brisbane HospitalHerston, Queensland, AustraliaRecruiting
Royal Adelaide HospitalAdelaide, South Australia, AustraliaRecruiting
The Alfred HospitalMelbourne, Victoria, AustraliaRecruiting
Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo, BrazilRecruiting
UNICAMP Universidade Estadual de CampinasSão Paulo, BrazilRecruiting
Specialized Hospital for Active Treatment of Hematological DiseasesSofia, BulgariaRecruiting
McMaster University - HamiltonHamilton, Ontario, CanadaRecruiting
Queen Mary HospitalHong Kong, Hong KongRecruiting

+ 18 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06003387