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Study identifier: NCT05996107 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of Ribociclib Administered Concurrently With Postoperative Radiation Therapy in Patients With High-Risk, HR+/HER2- Breast Cancer

Condition: Breast Cancer  ·  Sponsor: University of Michigan Rogel Cancer Center

PhasePhase 1
Planned participants30
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this research study is to determine the safety, tolerability and dose of Ribociclib when combined with adjuvant radiation in women with high-risk ER+ breast cancer. Once enrolled on study, patients will begin treatment with Ribociclib 400 mg daily at the same time as they initiate standard of care adjuvant radiation therapy- 50 Gy in 25 fractions or 42.56 Gy in 16 fractions +/- 10 Gy boost including comprehensive nodal. Paitents will continue treatment with Ribociclib for up to 6 weeks.

This description comes directly from the study's public registry record.

Talk to the study team

Cancer AnswerLine  ·  1-800-865-1125  ·  CancerAnswerLine@med.umich.edu

Always discuss trial participation with your own doctor first.

Locations (3)

University of MichiganAnn Arbor, Michigan, United StatesRecruiting
University of Michigan Health WestWyoming, Michigan, United StatesRecruiting
UHCMC Seidman Cancer CenterCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05996107