Condition: Antiphospholipid Syndrome · Ischemic Stroke · Transient Ischemic Attack · Sponsor: Seoul National University Hospital
Antiphospholipid syndrome (APS) has a close association with ischemic stroke; however, the optimal treatment strategy for APS-related stroke has yet to be established. The clinical guidelines suggest using warfarin for APS-related stroke, but these suggestions are largely based on retrospective studies from the 1990s and expert opinion, rather than high-quality clinical trials. Moreover, the evidence on the role of antiplatelet drugs other than aspirin (e.g., clopidogrel) in APS-related stroke is particularly limited. Considering the relatively young age of patients with APS and the high clinical burden of using warfarin, it is necessary to verify whether warfarin is essential. Thus, the investigators aim to compare clopidogrel-based antiplatelet therapy and warfarin as a secondary preventive medication for patients with APS-related stroke. APS-STROKE is an exploratory, multicenter, prospective, randomized, open, blinded-endpoint clinical trial. Adult patients with definite APS who have a history of ischemic stroke will be included. Patients with high-risk APS (triple positivity or persistently high titers of anti-cardiolipin or anti-β2-glycoprotein I antibodies), systemic lupus erythematous, or indications for continued antiplatelet or anticoagulant therapy will be excluded. Eligible patients will be 1:1 randomized to receive clopidogrel-based antiplatelet therapy or warfarin. Patients assigned to the clopidogrel-based antiplatelet therapy group will be permitted to use addi…
This description comes directly from the study's public registry record.
Wookjin Yang, MD, PhD · +82-2-2072-2114 · ywj_2002@naver.com
Seung-Hoon Lee, MD, PhD · +82-2-2072-1014 · sb0516@snu.ac.kr
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| Hallym University Sacred Heart Hospital | Anyang, South Korea | Recruiting |
| Busan Paik Hospital | Busan, South Korea | Recruiting |
| Pusan National University Hospital | Busan, South Korea | Recruiting |
| Chungbuk National University Hospital | Cheongju-si, South Korea | Recruiting |
| Hallym University Chuncheon Sacred Heart Hospital | Chuncheon, South Korea | Recruiting |
| Kangwon National University Hospital | Chuncheon, South Korea | Recruiting |
| Keimyung University Dongsan Medical Center | Daegu, South Korea | Recruiting |
| Yeungnam University Medical Center | Daegu, South Korea | Recruiting |
| Chungnam National University Hospital | Daejeon, South Korea | Recruiting |
| Hanyang University Guri Hospital | Guri-si, South Korea | Recruiting |
| Chonnam National University Hospital | Gwangju, South Korea | Recruiting |
| Chosun University Hospital | Gwangju, South Korea | Recruiting |
+ 20 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05995600