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Study identifier: NCT05995535 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal

Condition: Opiate Withdrawal Syndrome · Opioid Use  ·  Sponsor: University of Pennsylvania

PhasePhase 2
Planned participants150
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

A placebo-controlled trial in which male and female outpatients with an opioid use disorder who express interest in extended-release injectable naltrexone (XR-NTX) are randomized 1:1 to lofexidine/pregabalin or lofexidine/pregabalin placebo for withdrawal management and offered XR-NTX if after completing withdrawal.

This description comes directly from the study's public registry record.

Talk to the study team

Kyle M Kampman, MD  ·  215-746-2764  ·  Kampman@pennmedicine.upenn.edu

Matthew R Taylor  ·  215-746-0467  ·  matthew.taylor@pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Mountain Manor Treatment CenterBaltimore, Maryland, United StatesNot Yet Recruiting
University of Pennsylvania, Treatment Research CenterPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05995535